Holoprosencephaly Images for Baby Diagnostics by OB Images
Images: Patients A, B, C are alobar variants of holoprosencephaly with B and C due to Trisomy 13 at different gestational ages. Patient D represents semi-lobar holoprosencephaly at 27 6/7 weeks.
Above. Patient A. Cerebellar view 34 1/7 weeks gestation. Note elongated thalamus.
Above. Patient A. Fetal head circumference is at 7th percentile. Elongated thalamus. No cavum septi pellucidi (CSP) seen.
Above. Patient A. Holoprosencephaly Profile
Above. Patient A: Note monoventricle, fused thalamus; no infant interhemispheric fissure or falx. Diagnosis: holoprosencephaly, alobar variant.
Above. Patient B. 19 6/7 weeks gestation. Abnormal profile, likely monoventricle and fused thalamus, possible congenital heart defect.
Above. Patient B. Infant with abnormal lower extremities.
Above. Patient B. Abnormal hand with postaxial polydactyly.
Above. Patient B. Monoventricle, fused thalamus, with multiple fetal markers for aneuploidy. Diagnosis: Trisomy 13 with alobar holoprosencephaly.
Above. Holoprosencephaly Patient C. 17 5/7 weeks gestation. Brachycephaly, elongated thalamus, no CSP.
Above. Patient C. Elongation of thalamus, monoventricle and absence of CSP.
Above. Patient C. Sagittal view. Note monoventricle.
Above. Patient C. “Classic view” alobar holoprosencephaly with monoventricle, and fused thalamus. Karyotype: Trisomy 13.
Above. Patient D: 27 6/7 weeks gestation. Anterior monoventricle, no SCP.
Above. Patient D. Monoventricle present but with partial cleavage and rudimentary falx. Diagnosis: Semi-lobar Holoprosencephaly